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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however can result in problems with the trial design.
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프라그마틱 환수율 aim to mimic real-life situations and attain maximum external validity. They are usually ordered by policymakers and practitioners to help inform their decisions. They are also a good method to determine the causality between an intervention and its results. However, they shouldn't be used in lieu for explanation studies.
The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.
There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatics. It is important to remember that the majority of studies were conducted in primary care settings.